Myocardial Stiffness Evaluation Using Noninvasive Shear Wave Imaging in Healthy and Hypertrophic Cardiomyopathic Adults.
Villemain, O., M. Correia, E. Mousseaux, J. Baranger, S. Zarka, I. Podetti, G. Soulat, T. Damy, A. Hagège, M. Tanter et al.
JACC: Cardiovascular Imaging 12, no. 7 (2019): 1135–1145.
Résumé: © 2018 The Authors Objectives: The goal of our study was to investigate the potential of myocardial shear wave imaging (SWI) to quantify the diastolic myocardial stiffness (MS) (kPa) noninvasively in adult healthy volunteers (HVs) and its physiological variation with age, and in hypertrophic cardiomyopathy (HCM) populations with heart failure and preserved ejection function (HFpEF). Background: MS is an important prognostic and diagnostic parameter of the diastolic function. MS is affected by physiological changes but also by pathological alterations of extracellular and cellular tissues. However, the clinical assessment of MS and the diastolic function remains challenging. SWI is a novel ultrasound-based technique that has the potential to provide intrinsic MS noninvasively. Methods: We prospectively included 80 adults: 60 HV (divided into 3 groups: 20- to 39-year old patients [n = 20]; 40- to 59-year-old patients [n = 20]; and 60- to 79-year-old patients [n = 20]) and 20 HCM-HFpEF patients. Echocardiography, cardiac magnetic resonance imaging and biological explorations were achieved. MS evaluation was performed using an ultrafast ultrasound scanner with cardiac phased array. The fractional anisotropy of MS was also estimated. Results: MS increased significantly with age in the HV group (the mean MS was 2.59 ± 0.58 kPa, 4.70 ± 0.88 kPa, and 6.08 ± 1.06 kPa for the 20- to 40-year-old, 40- to 60-year-old, and 60- to 80-year-old patient groups, respectively; p < 0.01 between each group). MS was significantly higher in HCM-HFpEF patients than in HV patients (mean MS = 12.68 ± 2.91 kPa vs. 4.47 ± 1.68 kPa, respectively; p < 0.01), with a cut-off at 8 kPa (area under the curve = 0.993; sensitivity = 95%, specificity = 100%). The fractional anisotropy was lower in HCM-HFpEF (mean = 0.133 ± 0.073) than in HV (0.238 ± 0.068) (p < 0.01). Positive correlations were found between MS and diastolic parameters in echocardiography (early diastolic peak/early diastolic mitral annular velocity, r = 0.783; early diastolic peak/transmitral flow propagation velocity, r = 0.616; left atrial volume index, r = 0.623) and with fibrosis markers in cardiac magnetic resonance (late gadolinium enhancement, r = 0.804; myocardial T1 pre-contrast, r = 0.711). Conclusions: MS was found to increase with age in healthy adults and was significantly higher in HCM-HFpEF patients. Myocardial SWI has the potential to become a clinical tool for the diagnostic of diastolic dysfunction. (Non-invasive Evaluation of Myocardial Stiffness by Elastography [Elasto-Cardio]; NCT02537041)
Mots-Clés: diastolic function; echocardiography; myocardial stiffness; myocardium
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Optical complex media as universal reconfigurable linear operators.
Matthès, M. W., P. Del Hougne, J. De Rosny, G. Lerosey, and S. M. Popoff.
Optica 6, no. 4 (2019): 465–472.
Résumé: © 2019 Optical Society of America. Performing linear operations using optical devices is a crucial building block in many fields ranging from telecommunications to optical analog computation and machine learning. For many of these applications, key requirements are robustness to fabrication inaccuracies, reconfigurability, and scalability. We propose a way to perform linear operations using complex optical media such as multimode fibers or scattering media as a computational platform driven by wavefront shaping. Given a large random transmission matrix representing light propagation in such a medium, we can extract any desired smaller linear operator by finding suitable input and output projectors. We demonstrate this concept by finding input wavefronts using a spatial light modulator that cause the complex medium to act as a desired complex-valued linear operator on the optical field. We experimentally build several 16 × 16 operators and discuss the fundamental limits of the scalability of our approach. It offers the prospect of reconfigurable, robust, and easy-to-fabricate linear optical analog computation units.
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Scattering of gravity waves by a periodically structured ridge of finite extent.
Maurel, A., K. Pham, and J. J. Marigo.
Journal of Fluid Mechanics 871 (2019): 350–376.
Résumé: © 2019 Cambridge University Press. We study the propagation of water waves over a ridge structured at the subwavelength scale using homogenization techniques able to account for its finite extent. The calculations are conducted in the time domain considering the full three-dimensional problem to capture the effects of the evanescent field in the water channel over the structured ridge and at its boundaries. This provides an effective two-dimensional wave equation which is a classical result but also non-intuitive transmission conditions between the region of the ridge and the surrounding regions of constant immersion depth. Numerical results provide evidence that the scattering properties of a structured ridge can be strongly influenced by the evanescent fields, a fact which is accurately captured by the homogenized model.
Mots-Clés: shallow water flows; surface gravity waves; wave-structure interactions
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Imaging gigahertz zero-group-velocity Lamb waves.
Xie, Q., S. Mezil, P. H. Otsuka, M. Tomoda, J. Laurent, O. Matsuda, Z. Shen, and O. B. Wright.
Nature Communications 10, no. 1 (2019).
Résumé: © 2019, The Author(s). Zero-group-velocity (ZGV) waves have the peculiarity of being stationary, and thus locally confining energy. Although they are particularly useful in evaluation applications, they have not yet been tracked in two dimensions. Here we image gigahertz zero-group-velocity Lamb waves in the time domain by means of an ultrafast optical technique, revealing their stationary nature and their acoustic energy localization. The acoustic field is imaged to micron resolution on a nanoscale bilayer consisting of a silicon-nitride plate coated with a titanium film. Temporal and spatiotemporal Fourier transforms combined with a technique involving the intensity modulation of the optical pump and probe beams gives access to arbitrary acoustic frequencies, allowing ZGV modes to be isolated. The dispersion curves of the bilayer system are extracted together with the quality factor Q and lifetime of the first ZGV mode. Applications include the testing of bonded nanostructures.
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