Master
Development of a Retinal Digital Twin to model scattering and phase contrast retinal imaging
Development of AI-based Image Processing Pipeline for Retinal Imaging and Neurovascular Coupling Analysis at Cellular Level
Volumetric High-Speed Functional Imaging of the Living Human Retina
Extended-depth-of-focus for longer single-molecule tracking in cell nuclei
This Master-level internship explores how to push the limits of single-molecule microscopy by engineering phase-only masks on a deformable mirror to extend the depth of focus inside the cell nucleus. The project combines optics design, adaptive optics implementation, and single-molecule experiments to enable longer and more reliable tracking of transcription factors and DNA repair proteins in 3D nuclear environments. Candidates will gain hands-on experience in microscope development, quantitative imaging, and data analysis at the interface of physics and biology.
Internship- PhD offer : New thermalized light sources based on fluorescent scattering media
| Valentina KRACHMALNICOFF Tél. : 01 80 96 30 73  |
Advanced data-driven image processing in Python and MATLAB for medical research
The clinical investigation centers of the Quinze-Vingts Eye hospital and The Foundation Adolphe de Rothschild Hospital, and the Langevin Institute in Paris, have developed a unique expertise in the field of innovative computational laser Doppler imaging, optical coherence tomography, and the evaluation of their medical use in a variety of ocular pathologies, which increasingly demonstrates clinical relevance. Monitoring of tissue structure, blood flow, and cell activity in the retina by digital holography will improve understanding of the pathophysiology of visual loss. The digital calculation of the images acquired by optical interferometry is based on a wave propagation algorithm (laser radar- LIDAR), used to reconstruct the image from the data stream sampled by the camera.
