Digital holography for ophthalmology.

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Internship : Advanced digital holography for ophthalmology. Doppler imaging and computed tomography
CNRS UMR 7587 - ESPCI - Institut Langevin, 75005 Paris. Hôpital des XV-XX, 75012 Paris. Institut de la vision, 75012 Paris. Hôpital Fondation Rothschild 75019 Paris. Fondation Digital Holography 75005 Paris. The University of Pittsburgh Medical Center (UPMC), Pennsylvania, United States. Contact : Michael Atlan. micatlan (arobase)

The clinical investigation centers of the Quinze-Vingts Eye hospital and The Foundation Adolphe de Rothschild Hospital, and the Langevin Institute in Paris, have developed a unique expertise in the field of innovative computational laser Doppler imaging, optical coherence tomography, and the evaluation of their medical use in a variety of ocular pathologies, which increasingly demonstrates clinical relevance. Monitoring of tissue structure, blood flow, and cell activity in the retina by digital holography will improve understanding of the pathophysiology of visual loss. The digital calculation of the images acquired by optical interferometry is based on a wave propagation algorithm (laser radar- LIDAR), used to reconstruct the image from the data stream sampled by the camera.

Mission : A team of 3-4 interns will build and optimize coherent near-infrared laser interferometers for clinical measurements. They will develop a prototype imaging device that will be used to provide Doppler and 3D tomographic images of the eye. They will also conduct the experiments and perform data processing in Matlab and ImageJ in order to improve computed tomography and Doppler imaging. They will learn and improve coherent image formation by wave propagation, LIDAR algorithms, fluctuation analysis, statistical filtering and rephasing strategies including digital adaptive optics by Shack-Hartmann analysis in order to compensate eye aberrations. Support for software development is provided by the Digital Holography Foundation (, and through the Discord server Digital Holography (

Diffuse laser illumination for Maxwellian view Doppler holography of the retina
Full-field swept-source optical coherence tomography and laser Doppler holography :
Anterior segment, blood flow imaging, eye tracking, and transparency assessment :
Blood flow reversal in out-of-plane vessels :
Reverse contrast laser Doppler holography :
Real-time principal component analysis :
Spatio-temporal filtering :
Waveform analysis of human retinal and choroidal blood flow with laser Doppler holography :
Choroidal vasculature imaging with laser Doppler holography :
Swept-source optical coherence tomography by digital holography in real-time :
Doppler holography of the human retina :
High speed optical holography of retinal blood flow :
Doppler imaging of microvascular blood flow :
Holographic laser Doppler ophthalmoscopy :

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