Clément CABRIEL

Clément CABRIEL

Research scientist at CNRS
Tel.: +33 (0)1 80 96 30 59
Room: R37
Mail: clement.cabriel (arobase) espci.fr


Keywords
Single-molecule localization microscopy (SMLM), single-particle tracking (SPT), 3D super-resolution microscopy, data analysis, calibration, bioimaging, cell biology, DNA repair, single-molecule light-matter interaction, imaging of fabricated materials.

Research activity

My research mainly focuses on the development of single-molecule localization microscopy (SMLM) methods. SMLM is an super-resolution optical imaging approach that enables the study of the organization and dynamics of molecules at the nanoscale. My interdisciplinary approach allows me to apply these developments to various questions, particularly in the context of bioimaging, where SMLM unveils the coorganization of proteins or provides functional information about their interactions in living cells.

Aside from bioimaging, I also use SMLM in nanophotonics to study the light-matter interaction at the molecular scale by utilizing single molecules as probes of the local electromagnetic environment in plasmonic nanomaterials.

Part of my reseach work deals with the development of a single-molecule imaging method based on the use of event-based sensors (EBS). They are matrices of independent and asynchronous pixels that respond to light intensity variations rather than integrating the photons during a predefined exposure time. Compared to classical cameras, this technology is more suited to single-molecule imaging, as the emitters are often independent of each other. Through such an optimization of the temporal response, it is possible to achieve high spatio-temporal resolution SMLM in particular.

Within the Institut Langevin, I work in collaboration especially with Ignacio Izeddin for the development of SMLM methods and their application to DNA biology.

Open positions in the team (last updated in February 2025)

PhD offer (in co-supervision): Synuclein diffusion analysis in neurons using event-based super-resolution microscopy

We are looking for a motivated candidate for a co-supervised PhD funded by the program LightInParis. It aims to study the mobility of the protein alpha-synuclein in neurons to understand the molecular mechanisms underlying its accumulation, associated with certain neurodegenerative pathologies. The description of these mechanisms will rely on the use of event-based microscopy. The PhD will be supervised by Christian Specht (DHNS, Inserm, Université Paris-Saclay, Le Kremlin-Bicêtre), and co-supervised by Ignacio Izeddin and Clément Cabriel (Institut Langevin, ESPCI Paris, Université PSL, CNRS, Paris).
Eligibility criteria: the application needs to respect the MSCA-COFUND mobility rule. In particular, the candidate must not have studied/worked in France more than 12 months during the last 36 derniers months (at the date of the recruitment).
More information here
Application deadline: Wednesday March 26th 2025
Beginning of the PhD: October 1st, 2025. Duration: 3 years.
How to apply: please send your CV and a motivation letter to christian.specht (arobase) inserm.fr, clement.cabriel (arobase) espci.fr and ignacio.izeddin (arobase) espci.fr

Software/data processing engineer offer

We are looking for a motivated candidate for a software development and/or data analysis engineer contract of approximately 5 months (undergraduate or graduate level). We aim to develop tools to simplify and standardize event-based SMLM acquisitions and data processing. In particular, we would like to develop an acquisition software capable of controlling the acquisition instruments and displaying a rendering of the results in real time. We also plan to improve the post-acquisition data processing pipeline to make it more user-friendly, improve processing speed and develop visualization tools.
More information here
Beginning of the contract: between April and September 2025. Duration: approximately 5 months.
How to apply: please send your CV and a motivation letter to clement.cabriel (arobase) espci.fr and ignacio.izeddin (arobase) espci.fr

Publications

3D Single-Molecule Super-Resolution Imaging of Microfabricated Multiscale Fractal Substrates for Calibration and Cell Imaging
Cabriel, C., R. M. Córdova-Castro, E. Berenschot, A. Dávila-Lezama, K. Pondman, S. Le Gac, N. Tas, A. Susarrey-Arce, and I. Izeddin
ACS Applied Materials and Interfaces 17, no. 6, 9019-9034 (2025)
toggle visibility
3D topographies promote macrophage M2d-Subset differentiation
Carrara, S. C., A. Davila-Lezama, C. Cabriel, E. J. W. Berenschot, S. Krol, J. G. E. Gardeniers, I. Izeddin, H. Kolmar, and A. Susarrey-Arce
Materials Today Bio 24 (2024)
toggle visibility
3D-Architected Alkaline-Earth Perovskites
Winczewski, J. P., J. Arriaga Dávila, M. Herrera-Zaldívar, F. Ruiz-Zepeda, R. M. Córdova-Castr, C. R. Pérez De La Vega, C. Cabriel, I. Izeddin, H. Gardeniers, and A. Susarrey-Arce
Advanced Materials (2024)
toggle visibility
Event-based vision sensor for fast and dense single-molecule localization microscopy
Cabriel, C., T. Monfort, C. G. Specht, and I. Izeddin
Nature Photonics 17, no. 12, 1105-1113 (2023)
toggle visibility
Latest trends in bioimaging and building a proactive network of early-career young scientists around bioimaging in Europe
Valenta, H., N. Quiblier, V. Laghi, C. Cabriel, and J. Riti
Biology open 11, no. 12 (2022)
toggle visibility
Additive Manufacturing of 3D Luminescent ZrO2:Eu3+ Architectures
Winczewski, J., M. Herrera, C. Cabriel, I. Izeddin, S. Gabel, B. Merle, A. Susarrey Arce, and H. Gardeniers
Advanced Optical Materials, 2102758 (2022)
toggle visibility
Combining 3D single molecule localization strategies for reproducible bioimaging
Cabriel, C., N. Bourg, P. Jouchet, G. Dupuis, C. Leterrier, A. Baron, M. A. Badet-Denisot, B. Vauzeilles, E. Fort, and S. Lévêque-Fort
Nature communications 10, no. 1, 1980 (2019)
toggle visibility
Podosome Force Generation Machinery: A Local Balance between Protrusion at the Core and Traction at the Ring
Bouissou, A., A. Proag, N. Bourg, K. Pingris, C. Cabriel, S. Balor, T. Mangeat, C. Thibault, C. Vieu, G. Dupuis, E. Fort, S. Lévêque-Fort, I. Maridonneau-Parini, and R. Poincloux
ACS Nano 11, no. 4, 4028-4040 (2017)
toggle visibility

Top