Jean-Francois AUBRY

Jean-François AUBRY

Research director at CNRS
Invited Associate Professor at University of Virginia
PhD in Physics of University Paris VII
Graduated from École Normale Supérieure, Cachan

Tel.: +33 (0)1 80 96 30 38
Fax.: +33 (0)1 80 96 33 55
Room: C-09
Mail: Jean-Francois.Aubry (arobase) espci.fr

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PhD Manuscript
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Accreditation to supervise research Manuscript (HDR)

Scientific Activities

President of the International Society for Therapeutic Ultrasound

Member of the Research Advisory Committee of the Focused Ultrasound Foundation

Associate Editor of Medical Physics journal

Referee for Current Biology, Physics in Medicine and Biology, Ultrasound in Medicine and Biology, Journal of the Acoustical Society of America, International Journal of Hyperthermia, IEEE TUFFC, IEEE TBME, IEEE TMI, Metrologia, ...

Publications & Patents

56 Papers in international peer-reviewed journals

4 Patents in the field of Ultrasound and Wave Physics

33 Invited Talks or Lectures in international conferences

Prizes and Awards

Frederic Lizzi Early Career Award of the International Society for Therapeutic Ultrasound (New York, 2011)

Bronze medal of the CNRS (Paris, 2011)

List of publications

Non-Invasive, Focal Disconnection Of Brain Circuitry Using Magnetic Resonance-Guided Low-Intensity Focused Ultrasound To Deliver A Neurotoxin.
Zhang, Y., H. Tan, E. H. Bertram, J. - F. Aubry, M. - B. Lopes, J. Roy, E. Dumont, M. Xie, Z. Zuo, A. L. Klibanov et al.
Ultrasound In Medicine And Biology 42, no. 9 (2016): 2261–2269.
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MR-Guided Transcranial Focused Ultrasound.
Aubry, J. - F., and M. Tanter.
Advances in experimental medicine and biology 880 (2016): 97–111.
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Defining The Optimal Age For Focal Lesioning In A Rat Model Of Transcranial Hifu.
Zhang, Y., J. - F. Aubry, J. Zhang, Y. Wang, J. Roy, J. F. Mata, W. Miller, E. Dumont, M. Xie, K. Lee et al.
Ultrasound In Medicine And Biology 41, no. 2 (2015): 449–455.
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Intracranial inertial cavitation threshold and thermal ablation lesion creation using MRI-guided 220-kHz focused ultrasound surgery: preclinical investigation.
Xu, Z., C. Carlson, J. Snell, M. Eames, A. Hananel, M. B. Lopes, P. Raghavan, C. - C. Lee, C. - P. Yen, D. Schlesinger et al.
Journal Of Neurosurgery 122, no. 1 (2015): 152–161.
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T1-weighted MRI as a substitute to CT for refocusing planning in MR-guided focused ultrasound.
Wintermark, M., N. J. Tustison, W. J. Elias, J. T. Patrie, W. Xin, N. Demartini, M. Eames, S. Sumer, B. Lau, A. Cupino et al.
Physics In Medicine And Biology 59, no. 13 (2014): 3599–3614.
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Transcranial ultrasound neuromodulation of the contralateral visual field in awake monkey.
Deffieux, T., Y. Younan, M. Tanter, J. - F. Aubry, N. Wattiez, and P. Pouget.
In IEEE International Ultrasonics Symposium, 1–4., 2013.
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Non-invasive ultrasonic surgery of the brain in non-human primates.
Marquet, F., A. - L. Boch, M. Pernot, G. Montaldo, D. Seilhean, M. Fink, M. Tanter, and J. - F. Aubry.
Journal Of The Acoustical Society Of America 134, no. 2 (2013): 1632–1639.
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Trans-cranial focused ultrasound without hair shaving: feasibility study in an ex vivo cadaver model.
Eames, M. D. C., A. Hananel, J. W. Snell, N. F. Kassell, and J. - F. Aubry.
Journal of Therapeutic Ultrasound 1 (2013): 24.
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Focused ultrasound therapy: Current status and potential applications in neurosurgery.
Dervishi, E., J. - F. Aubry, J. - Y. Delattre, and A. - L. Boch.
Neurochirurgie 59, no. 6 (2013): 201–209.
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Low-Intensity Focused Ultrasound Modulates Monkey Visuomotor Behavior.
Deffieux, T., Y. Younan, N. Wattiez, M. Tanter, P. Pouget, and J. - F. Aubry.
Current Biology (2013).
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How minute sooglossid frogs hear without a middle ear.
Boistel, R., T. Aubin, P. Cloetens, F. Peyrin, T. Scotti, P. Herzog, J. Gerlach, N. Pollet, and J. - F. Aubry.
Proceedings of the National Academy of Sciences of the United States of America 110, no. 38 (2013): 15360–15364.
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Keyhole acceleration for magnetic resonance acoustic radiation force imaging (MR ARFI).
Paquin, R., A. Vignaud, L. Marsac, Y. Younan, S. Lehéricy, M. Tanter, and J. - F. Aubry.
Magnetic Resonance Imaging (2013).
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Transcranial high intensity focused ultrasound therapy guided by 7 TESLA MRI in a rat brain tumour model: A feasibility study.
Dervishi, E., B. Larrat, M. Pernot, C. Adam, Y. Marie, M. Fink, J. - Y. Delattre, A. - L. Boch, M. Tanter, and J. - F. Aubry.
International Journal of Hyperthermia 29, no. 6 (2013): 598–608.
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Time reversal of photoacoustic waves.
Bossy, E., K. Daoudi, A. - C. Boccara, M. Tanter, J. - F. Aubry, G. Montaldo, and M. Fink.
Applied Physics Letters 89, no. 18 (2006): 184108.
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Photoacoustic guidance of high intensity focused ultrasound with selective optical contrasts and time-reversal.
Funke, A. R., J. - F. Aubry, M. Fink, A. - C. Boccara, and E. Bossy.
Applied Physics Letters 94, no. 5 (2009): 054102.
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Mechanisms of attenuation and heating dissipation of ultrasound in the skull bone: Comparison between simulation models and experiments.
Pinton, G., M. Pernot, E. Bossy, J. - F. Aubry, M. Muller, and M. Tanter.
In Proceedings – IEEE Ultrasonics Symposium, 225–228., 2010.
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Statistics of Acoustically Induced Bubble-Nucleation Events in in Vitro Blood: A Feasibility Study.
Gateau, J., N. Taccoen, M. Tanter, and J. - F. Aubry.
Ultrasound in Medicine and Biology (2013).
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A magnetic resonance imaging, histological, and dose modeling comparison of focused ultrasound, radiofrequency, and Gamma Knife radiosurgery lesions in swine thalamus.
Elias, W. J., M. Khaled, J. D. Hilliard, J. - F. Aubry, R. C. Frysinger, J. P. Sheehan, M. Wintermark, and M. B. Lopes.
Journal of Neurosurgery 119, no. 2 (2013): 307–317.
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Influence of the pressure field distribution in transcranial ultrasonic neurostimulation.
Younan, Y., T. Deffieux, B. Larrat, M. Fink, M. Tanter, and J. - F. Aubry.
Medical Physics 40, no. 8 (2013).
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Targeting accuracy of transcranial magnetic resonance-guided high-intensity focused ultrasound brain therapy: A fresh cadaver model: Laboratory investigation.
Chauvet, D., L. Marsac, M. Pernot, A. - L. Boch, R. Guillevin, N. Salameh, L. Souris, L. Darrasse, M. Fink, M. Tanter et al.
Journal of Neurosurgery 118, no. 5 (2013): 1046–1052.
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High-intensity focused ultrasound.
Holland, G. A., O. Mironov, J. - F. Aubry, A. Hananel, and J. B. Duda.
Ultrasound Clinics 8, no. 2 (2013): 213–226.
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High-intensity therapeutic ultrasound: Metrological requirements versus clinical usage.
Aubry, J. - F.
Metrologia 49, no. 5 (2012): S259–S266.
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Monitoring of cornea elastic properties changes during UV-A/riboflavin-induced corneal collagen cross-linking using supersonic shear wave imaging: A pilot study.
Nguyen, T. - M., J. - F. Aubry, D. Touboul, M. Fink, J. - L. Gennisson, J. Bercoff, and M. Tanter.
Investigative Ophthalmology and Visual Science 53, no. 9 (2012): 5948–5954.
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Direct phase projection and transcranial focusing of ultrasound for brain therapy.
Pinton, G. F., J. - F. Aubry, and M. Tanter.
IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control 59, no. 6 (2012): 1149–1159.
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Attenuation, scattering, and absorption of ultrasound in the skull bone.
Pinton, G., J. - F. Aubry, E. Bossy, M. Muller, M. Pernot, and M. Tanter.
Medical Physics 39, no. 1 (2012): 299–307.
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Numerical prediction of frequency dependent 3D maps of mechanical index thresholds in ultrasonic brain therapy.
Pinton, G., J. - F. Aubry, M. Fink, and M. Tanter.
Medical Physics 39, no. 1 (2012): 455–467.
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Assessment of shear anisotropy using supersonic shear imaging with rotating arrays: In vivo evidence of cornea elastic anisotropy.
Nguyen, T. - M., J. - F. Aubry, D. Touboul, J. Bercoff, and M. Tanter.
In IEEE International Ultrasonics Symposium, IUS, 1278–1280., 2011.
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In vivo bubble nucleation probability in sheep brain tissue.
Gateau, J., J. - F. Aubry, D. Chauvet, A. - L. Boch, M. Fink, and M. Tanter.
Physics in Medicine and Biology 56, no. 22 (2011): 7001–7015.
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Synchronized passive imaging of single cavitation events.
Gateau, J., J. - F. Aubry, M. Pernota, D. Chauvet, A. - L. Boch, M. Fink, and M. Tanter.
In AIP Conference Proceedings, 79–84. Vol. 1359., 2011.
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Effects of nonlinear ultrasound propagation on high intensity brain therapy.
Pinton, G., J. - F. Aubry, M. Fink, and M. Tanter.
Medical Physics 38, no. 3 (2011): 1207–1216.
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Combined passive detection and ultrafast active imaging of cavitation events induced by short pulses of high-intensity ultrasound.
Gateau, J., J. - F. Aubry, M. Pernot, M. Fink, and M. Tanter.
IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control 58, no. 3 (2011): 517–532.
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Numerical prediction of frequency dependent 3D maps of mechanical index thresholds in ultrasonic brain therapy.
Pinton, G. F., J. - F. Aubry, M. Fink, and M. Tanter.
In Proceedings – IEEE Ultrasonics Symposium, 2258–2261., 2010.
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Adaptive focusing of transcranial therapeutic ultrasound using MR AcousticRadiation Force Imaging in a clinical environment.
Marsac, L., B. Larrat, M. Pernot, B. Robert, M. Fink, J. - F. Aubry, and M. Tanter.
In Proceedings – IEEE Ultrasonics Symposium, 991–994., 2010.
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High intensity focused ultrasound for transcranial therapy of brain lesions and disorders.
Aubry, J. - F., L. Marsac, M. Pernot, B. Robert, A. - L. Boch, D. Chauvet, N. Salameh, L. Souris, L. Darasse, J. Bittoun et al.
IRBM 31, no. 2 (2010): 87–91.
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Non invasive transcostal focusing based on the decomposition of the time reversal operator: In vitro validation.
Cochard, É., C. Prada, J. - F. Aubry, and M. Fink.
In AIP Conference Proceedings, 131–135. Vol. 1215., 2010.
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MR-guided transcranial brain HIFU in small animal models.
Larrat, B., M. Pernot, J. - F. Aubry, E. Dervishi, R. Sinkus, D. Seilhean, Y. Marie, A. - L. Boch, M. Fink, and M. Tanter.
Physics in Medicine and Biology 55, no. 2 (2010): 365–388.
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Transcranial ultrasonic therapy based on time reversal of acoustically induced cavitation bubble signature.
Gâteau, J., L. Marsac, M. Pernot, J. - F. Aubry, M. Tanter, and M. Fink.
IEEE Transactions on Biomedical Engineering 57, no. 1 (2010): 134–144.
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Effects of nonlinearity on propagation through the skull.
Pinton, G. F., J. - F. Aubry, M. Tanter, and M. Fink.
In Proceedings – IEEE Ultrasonics Symposium., 2009.
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Non-invasive transcranial ultrasound therapy based on a 3D CT scan: Protocol validation and in vitro results.
Marquet, F., M. Pernot, J. - F. Aubry, G. Montaldo, L. Marsac, M. Tanter, and M. Fink.
Physics in Medicine and Biology 54, no. 9 (2009): 2597–2613.
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Ultrafast Imaging of Ultrasound Contrast Agents.
Couture, O., S. Bannouf, G. Montaldo, J. - F. Aubry, M. Fink, and M. Tanter.
Ultrasound in Medicine and Biology 35, no. 11 (2009): 1908–1916.
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Cavitation bubble generation and control for HIFU transcranial adaptive focusing.
Gâteau, J., L. Marsac, M. Pernot, J. - F. Aubry, M. Tanter, and M. Fink.
In AIP Conference Proceedings, 18–22. Vol. 1113., 2009.
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Time-reversal focusing of therapeutic ultrasound on targeted microbubbles.
Couture, O., J. - F. Aubry, M. Tanter, and M. Fink.
Applied Physics Letters 94, no. 17 (2009).
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Radiation force localization of HIFU therapeutic beams coupled with Magnetic Resonance-Elastography treatment monitoring, In vivo application to the rat brain.
Larrat, B., M. Pernot, J. - F. Aubry, R. Sinkus, M. Tanter, and M. Fink.
In Proceedings – IEEE Ultrasonics Symposium, 451–454., 2008.
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Tissue harmonics cancellation using time-reversal.
Couture, O., J. - F. Aubry, G. Montaldo, M. Tanter, and M. Fink.
In Proceedings – IEEE Ultrasonics Symposium, 1104–1107., 2008.
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Molecular focusing of high-intensity ultrasound Time-reversal focusing applied to targeted ultrasound contrast agents.
Couture, O., J. - F. Aubry, M. Tanter, and M. Fink.
In Proceedings – IEEE Ultrasonics Symposium, 455–458., 2008.
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Suppression of tissue harmonics for pulse-inversion contrast imaging using time reversal.
Couture, O., J. - F. Aubry, G. Montaldo, M. Tanter, and M. Fink.
Physics in Medicine and Biology 53, no. 19 (2008): 5469–5480.
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Transcostal high-intensity-focused ultrasound: Ex vivo adaptive focusing feasibility study.
Aubry, J. - F., M. Pernot, F. Marquet, M. Tanter, and M. Fink.
Physics in Medicine and Biology 53, no. 11 (2008): 2937–2951.
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Optimal adaptive focusing through heterogeneous media with the minimally invasive inverse filter.
Vignon, F., J. De Rosny, J. - F. Aubry, and M. Fink.
Journal of the Acoustical Society of America 122, no. 5 (2007): 2715–2724.
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High power phased array prototype for clinical high intensity focused ultrasound: Applications to transcostal and transcranial therapy.
Pernot, M., J. - F. Aubry, M. Tanter, F. Marquet, G. Montaldo, A. - L. Boch, M. Kujas, D. Seilhean, and M. Fink.
In Annual International Conference of the IEEE Engineering in Medicine and Biology – Proceedings, 234–237., 2007.
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Ultrasonic arrays: New therapeutic developments.
Aubry, J. - F., M. Pernot, M. Tanter, G. Montaldo, and M. Fink.
Journal de Radiologie 88, no. 11 C2 (2007): 1801–1809.
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Non-invasive transcranial brain therapy guided by CT scans: An in vivo monkey study.
Marquet, F., M. Pernot, J. - F. Aubry, G. Montaldo, M. Tanter, A. - L. Boch, M. Kujas, D. Seilhean, and M. Fink.
In AIP Conference Proceedings, 554–560. Vol. 911., 2007.
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In vivo transcranial brain surgery with an ultrasonic time reversal mirror.
Pernot, M., J. - F. Aubry, M. Tanter, A. - L. Boch, F. Marquet, M. Kujas, D. Seilhean, and M. Fink.
Journal of Neurosurgery 106, no. 6 (2007): 1061–1066.
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Compensating for bone interfaces and respiratory motion in high-intensity focused ultrasound.
Tanter, M., M. Pernot, J. - F. Aubry, G. Montaldo, F. Marquet, and M. Fink.
International Journal of Hyperthermia 23, no. 2 (2007): 141–151.
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Non-invasive transcranial ultrasound therapy guided by CT-scans.
Marquet, F., M. Pernot, J. - F. Aubry, G. Montaldo, M. Tanter, and M. Fink.
In Annual International Conference of the IEEE Engineering in Medicine and Biology – Proceedings, 683–687., 2006.
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In-vivo non-invasive motion tracking and correction in High Intensity Focused Ultrasound therapy.
Marquet, F., M. Pernot, J. - F. Aubry, M. Tanter, G. Montaldo, and M. Fink.
In Annual International Conference of the IEEE Engineering in Medicine and Biology – Proceedings, 688–691., 2006.
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The Stokes relations linking time reversal and the inverse filter.
Vignon, F., J. - F. Aubry, A. Saez, M. Tanter, D. Cassereau, G. Montaldo, and M. Fink.
Journal of the Acoustical Society of America 119, no. 3 (2006): 1335–1346.
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High resolution ultrasonic brain imaging: Adaptive focusing based on twin-arrays.
Vignon, F., J. - F. Aubry, M. Tanter, and M. Fink.
In ICASSP, IEEE International Conference on Acoustics, Speech and Signal Processing – Proceedings, V973–V976. Vol. V., 2005.
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Dual-arrays brain imaging prototype: Experimental in Vitro results.
Vignon, F., J. - F. Aubry, M. Tanter, A. Margoum, M. Fink, and J. M. Lecoeur.
In Proceedings – IEEE Ultrasonics Symposium, 504–507. Vol. 1., 2005.
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Predicting and preventing skull overheating in non invasive brain HIFU treatment protocols.
Pernot, M., J. - F. Aubry, M. Tanter, and M. Fink.
In AIP Conference Proceedings, 147–150. Vol. 754., 2005.
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Adaptive focusing for ultrasonic transcranial brain therapy: First in vivo investigation on 22 sheep.
Pernot, M., J. - F. Aubry, M. Tanter, A. L. Boch, M. Kujas, and M. Fink.
In AIP Conference Proceedings, 174–177. Vol. 754., 2005.
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Prediction of the skull overheating during high intensity focused ultrasound transcranial brain therapy.
Pernot, M., J. - F. Aubry, M. Tanter, F. Andre, and M. Fink.
In Proceedings – IEEE Ultrasonics Symposium, 1005–1008. Vol. 2., 2004.
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Ultrasonic transcranial brain therapy: First in vivo clinical investigation on 22 sheep using adaptive focusing.
Pernot, M., J. - F. Aubry, M. Tanter, A. L. Boch, M. Kujas, and M. Fink.
In Proceedings – IEEE Ultrasonics Symposium, 1013–1016. Vol. 2., 2004.
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Ultrasonically induced necrosis through the rib cage based on adaptive focusing: Ex vivo experiments.
Pernot, M., J. - F. Aubry, M. Tanter, and M. Fink.
In Proceedings of the IEEE Ultrasonics Symposium, 833–836. Vol. 1., 2003.
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High power transcranial beam steering for ultrasonic brain therapy.
Pernot, M., J. - F. Aubry, M. Tanter, J. - L. Thomas, and M. Fink.
Physics in Medicine and Biology 48, no. 16 (2003): 2577–2589.
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Experimental demonstration of noninvasive transskull adaptive focusing based on prior computed tomography scans.
Aubry, J. - F., M. Tanter, M. Pernot, J. - L. Thomas, and M. Fink.
Journal of the Acoustical Society of America 113, no. 1 (2003): 84–93.
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Optimal focusing by spatio-temporal inverse filter. I. Basic principles.
Tanter, M., J. - F. Aubry, J. Gerber, J. - L. Thomas, and M. Fink.
Journal of the Acoustical Society of America 110, no. 1 (2001): 37–47.
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Optimal focusing by spatio-temporal inverse filter. II. Experiments. Application to focusing through absorbing and reverberating media.
Aubry, J. - F., M. Tanter, J. Gerber, J. - L. Thomas, and M. Fink.
Journal of the Acoustical Society of America 110, no. 1 (2001): 48–58.
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